Biological Activity of Secretory IgA

Mucosal secretory IgA and secretory piece in adult coeliac disease.

Immunofluorescence studies with specific antisera to secretory IgA (11S IgA) and secretory piece were carried out on the jejunal mucosa of nine patients with adult coeliac disease (treated and untreated). The results were compared with those obtained in four normal patients and in four patients with local and systemic IgA (7S) deficiency. 11S IgA and secretory piece were localized to the upper ...

In vitro comparison of the biologic activities of monoclonal monomeric IgA, polymeric IgA, and secretory IgA.

Secretory IgA (S-IgA), a major humoral mediator of mucosal immunity, is a polymeric Ig containing an unusual extra polypeptide, secretory component (SC), added during transcytosis through epithelial cells. Polymeric S-IgA is more effective than monomeric IgA (mIgA) and IgG in neutralizing viruses. It is not known whether this increased efficacy is due solely to the polymeric structure of the mo...

Secretory IgA Monoclonal Monomeric IgA, Polymeric IgA, and In Vitro Comparison of the Biologic Activities of

Relaxation training and breast milk secretory IgA.

OBJECTIVE To evaluate the hypothesis that breast-feeding women who participate in relaxation training will have increased secretory IgA (sIgA) levels in their breast milk compared with women not receiving training. DESIGN Nonrandomized control trial of a convenience sample. SETTING Women were recruited from the postpartum floor of a university teaching hospital. The intervention took place ...

Urinary secretory IgA after nutritional rehabilitation.

We studied the secretory IgA (sIgA) response of the mucosal urinary tract of malnourished children before and after nutritional rehabilitation. sIgA concentration (mg/l) was determined by ELISA in 187 children aged 3 months to 5 years. The children, who frequented a day care center, were divided into four groups, according to nutritional status: 57 were eutrophic, 49 were undergrown, 57 were mo...